Well, it doesn't exist except in your own head. We can argue ballistics, drop chart, energy, flat shooting, etc...., but its whatever you think the best cartridge is.
There's two types of shooters; One who wants a flat shooting round, who doesn't want to hold over out to 300yds and then theres the energy guys, the guys who want whatever you shoot to not get up or spin, they want one shot one kill and usually these people are the ones who know their gun inside and out, know what the hold over is out to 500yds and also use some type of mil or moa scope.
Neither is wrong, its about personal preference.
The faster calibers in the AR15 platform are the 204, 223, 22 Nosler, 24 Nosler(Super 6 SD)and even the 24 Valkyrie and most of the AR10's are quite fast, like the 22-250(see our video here), 243 and the 6mm Creedmoor. There are many wildcats in this category as well.
The slower but hard hitting category would include the 6.8spc, 6.5 Grendel, 300blk and even a 223 with heavy bullets. The AR10 version is the 308 and 6.5 Creedmoor.
Ask yourself if you want a hard hitting caliber or a laser beam. I know a lot of folks will say both and if thats the case, stick with the AR10 in 22-250 or 243.
Remember there is no "Best", what I think is the best is what someone else might laugh at, what they like, I might think disagree.
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